Sep 2026
Nucleolin shields PTBP1 from autophagic degradation to sustain gemcitabine resistance in bladder cancer.
Chemoresistance is a principal cause of treatment failure in bladder cancer (BLCA), yet the mechanisms that actively maintain resistance remain poorly defined. Gemcitabine (GEM) resistance is classically attributed to impaired drug uptake via human equilibrative nucleoside transporter 1 (hENT1) and activation of pro-su...
Yunyi Liu, Ya-Tao Wu, Juan Li et al.
· Drug resistance updates · 0 citations