Author

Xiao Xu

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Review Open access Jul 2026

Presenilin Deficiency Beyond Amyloid: Lessons from Presenilin 1/2 Conditional Double-Knockout Mice on Synaptic Failure, Calcium Dyshomeostasis, and Inflammation-Driven Alzheimer's disease.

It is concluded that PS integrate vesicular release machinery with trophic and inflammatory homeostasis; their loss initiates a multi-scale failure cascade that redefines early AD-related neurodegeneration beyond Aβ.

Guang Yang, Xiao Xu, Ying Xu · Brain Research Bulletin · 0 citations

Review Open access Jul 2026

TREM2 as a central immunometabolic hub in Alzheimer’s disease: linking microglial states, lipid stress, and disease-stage-specific intervention

The latest insights into TREM2 biology are synthesized, focusing on the role of TREM2 in microglial state transitions, lipid metabolism, and myelin turnover, and the pathophysiological relevance of soluble TREM2 (sTREM2) and AD-associated TREM2 variants are examined.

Guang Yang, Xiao Xu, Ying Xu · Frontiers in Immunology · 0 citations