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Author

Xiao-Yan Wang

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Sep 2026

Abstract A120: Tumor-intrinsic MYC promotes a skeletal muscle-involving wasting phenotype in pancreatic ductal adenocarcinoma

Cancer cachexia is defined by an ongoing loss of skeletal muscle mass, with or without loss of adipose tissue, and is particularly prevalent and severe in pancreatic ductal adenocarcinoma (PDAC). However, whether muscle and adipose wasting represent separable components of cachexia and are differentially shaped by tu...

Ting-Ting Zhang, Fa-Ming Zhao, Xiao-Yan Wang et al. · 0 citations
Sep 2026

Abstract B126: Targeting USP36 as a therapeutic strategy for high-MYC expressing pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by poor therapeutic response and aggressive disease progression driven heavily by the c-MYC oncoprotein. Ubiquitin-specific protease 36 (USP36) is a nucleolar deubiquitinating enzyme that enhances the stability of criti...

Assmaa ElSheikh, Ping-Chuan Zhang, Xiao-Yan Wang et al. · 0 citations

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