Author

Xiao-Yi Fan

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Open access Aug 2026

Orthoflaviviruses use diverse binding modes to engage LDLR family receptors

Orthoflaviviruses are major human pathogens that cause substantial morbidity and mortality worldwide. The viral envelope (E) mediates entry of orthoflaviviruses into host cells by interacting with cellular receptors, including members of the low-density lipoprotein receptor (LDLR) family. Here, we determined cryo-elect...

Chenggong Ji, Laurentia V. Tjang, Biswajit Das et al. · bioRxiv · 0 citations

Open access Jul 2026

Molecular basis for chikungunya virus recognition of a mosquito-specific receptor

Alphaviruses are arthropod-borne viruses that recognize cellular receptors in both vertebrate hosts and mosquito vectors to complete their transmission cycle, yet how they maintain recognition of receptors across evolutionarily divergent host species remains unresolved. Among alphaviruses, chikungunya virus (CHIKV), wh...

Xiao-Yi Fan, Wanyu Li, Jesse S. Plung et al. · bioRxiv · 0 citations

Open access Sep 2026

Structure and operating principles of a monkeypox virus replisome.

Poxviruses are double-stranded DNA viruses with large genomes. Among them, monkeypox virus (MPXV) has been responsible for two recent public health emergencies as declared by the World Health Organization1. The MPXV polymerase comprises three subunits-a catalytic subunit (F8) and a heterodimeric processivity factor (A2...

Zi-Shuo Yu, Pradeep Sathyanarayana, Joel M. J. Tan et al. · Nature · 0 citations