Author

Xiao-Yu Lin

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Review Open access Aug 2026

Decoding the Bile Acid-Mitochondria Axis: Implications for Disease Management and Therapeutic Opportunities.

Bile acids, as cholesterol metabolites, orchestrate a regulatory network with mitochondrial quality control (MQC) through nuclear receptor FXR, membrane receptor TGR5, and other signaling molecules, modulating mitochondrial biogenesis, dynamic equilibrium, selective autophagy, and redox homeostasis. TGR5 promotes PGC-1...

Xue-Ru Jia, Ze-Han Zhang, Xiao-Yu Lin et al. · Pharmacological Research · 0 citations

Aug 2026

Phytolacca acinosa Roxb. induces intestinal toxicity through the histamine-MLCK-tight junction axis: Integrated evidence from proteomics, metabolomics, intestinal organoids and epithelial barrier validation.

Phytolacca acinosa Roxb. (PR) is a saponin-rich medicinal plant associated with gastrointestinal toxicity, but the mechanisms underlying PR-induced intestinal barrier injury remain unclear. In this study, raw PR extract was analytically characterized by UPLC-ZenoTOF-MS/MS, confirming triterpenoid saponins as the predom...

Yu Qi, Xiao-Yu Lin, Yang Huang et al. · Toxicology Letters · 0 citations