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Author

Xiao-Yu Liu

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Open access Sep 2026

scGSI: Graph-guided self-supervised integration of paired single-cell multi-omics

Paired single-cell multi-omics technologies provide direct within-cell correspondence across molecular layers and offer a powerful route to dissecting cellular heterogeneity and regulatory relationships. However, effective integration requires more than modality mixing: a useful model must accurately align paired cells...

Xiang Chen, Zi-Han Yang, Xiao-Yu Liu et al. · 0 citations
Jul 2026

CoAff-DTI: Fine-grained drug-target interaction prediction using pre-trained language models and affinity-guided mechanisms

CoAff-DTI is proposed, an end-to-end deep learning framework designed to enhance multi-scale interaction modeling for DTI prediction and consistently outperforms state-of-the-art methods on multiple benchmark datasets.

Jia Peng, Xiaoyu Liu, Lei Wang et al. · 0 citations

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