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Author

Xiao-Yu Yang

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Sep 2026

ERO1A is a hypoxia-ER bridge in NSCLC: from pan-cancer identification to a dual-reporter visualization system.

A dual-reporter system, ERO1Ap2-miRFP670/5HRE-EGFP, driven by the ERO1A promoter and hypoxia response element (HRE), enables real-time, visual monitoring of the dynamic interplay between ER function and the tumor hypoxic microenvironment by simultaneously tracking ERO1A promoter activity and HIF-1α pathway activation.

Xiao-Yu Yang, Peng Chang, Dao-Yi Quan et al. · 0 citations
Aug 2026

HIF-1α-mediated regulation of ATG7 and KDM5C in ferroptosis.

This work provides a powerful visualizable platform to dynamically study the crosstalk between HIF-1α and ferroptosis in liver cancer, facilitating the exploration of hypoxia-ferroptosis interplay in hepatocarcinogenesis and therapeutic response.

Kuo-Ye Tian, Peng Chang, Xiao-Yu Yang et al. · 0 citations

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