Author

Xiao-Yuan Wang

2 papers indexed here

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Open access Sep 2026

Coordinated cellular programmes distinguish responses to neoadjuvant PD-L1 blockade and potentiate combinatorial immunotherapy in ESCC.

BACKGROUND Programmed death ligand 1 (PD-L1) blockade offers new therapeutic options for oesophageal squamous cell carcinoma (ESCC); however, the underlying mechanisms and associated biomarkers that determine treatment response remain unclear. OBJECTIVE We delineate the mechanisms underlying the response and resistan...

Si Li, Ji-Yu Guo, Jian-Qun Ma et al. · Gut · 0 citations

Open access Aug 2026

Mutant TP53 hijacks RNA-splicing factor RBM28 to suppress double-stranded RNA triggered antitumor immunity

TP53 mutation may not only compromise its multifaceted tumor-suppressive functions but also confer oncogenic properties. Here, we demonstrate that DNA-binding domain mutations of TP53 unexpectedly confer a transcriptional regulatory function, directly driving RNA-splicing factor RBM28 overexpression. Overexpressed RBM2...

Tao Xiang, Zi-Yi He, Xiao Hu et al. · Nature Communications · 0 citations