Author

Xiaoyun Li

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Open access Oct 2026

Formononetin Protects Osteoblasts Against Oxidative Stress and Attenuates Ovariectomy-Induced Bone Loss in Association with MAPK/AP-1 and NRF2 Signaling

Postmenopausal osteoporosis (PMOP) is associated with estrogen deficiency and oxidative stress (OS), which impair osteoblast survival and osteogenic function. Formononetin (FMN) is a phytoestrogen with antioxidant properties, but its protective effects on osteoblasts under OS and the signaling pathways associated with...

Shu-Hua Liu, Ruo-Lin Wang, Chenhaoyu Liu et al. · Antioxidants · 0 citations

Oct 2026

Bushen Huoxue Formula promotes osteoporotic fracture healing by CGRP-mediated dual regulation of BMSCs-osteoclasts balance through modulating mitochondrial energy metabolism.

Osteoporotic fracture (OPF) is a serious complication that severely impairs the quality of life. Bushen Huoxue Formula (BHF), a clinically established prescription based on the TCM principle of "tonifying the kidney and activating blood circulation," has been widely used to treat osteoporosis. However, its efficacy in...

Qing Lin, Bi-Yi Zhao, Zhu-Xuan Liu et al. · Phytomedicine · 0 citations

Open access Jul 2026

Shared Genetic Architecture Between Epigenetic Aging and Musculoskeletal Diseases

The results support a prioritized genomic map with substantial instrument- and model-specific uncertainty, and disease-to-clock signals were richer than clock-to-disease signals, GrimAA shared polygenic architecture with osteoarthritis, and selected loci showed strong shared-variant evidence.

Wei Xu, Xuan-Yu Zhang, Bi-yi Zhao et al. · Genes · 0 citations