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Xiao-Zhi Hu

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Open access Oct 2026

Bridging innate and adaptive immunity: A bispecific SIRPαD1-αPCSK9 fusion protein reprograms macrophages for durable tumor clearance.

Dual targeting synergistically enhances phagocytosis, preserves antigen cross-presentation, and reprograms tumor microenvironment toward an immunostimulatory state, and activates innate and adaptive antitumor immunity.

Cai-Ling Xu, Kai-Cheng Zhou, Xiao-Zhi Hu et al. · 0 citations

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