Author

Xiaodong Hu

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Open access Jul 2026

Structural insights into the binding of CX-5461 and MTR-106 to G-quadruplex DNA

The molecular basis of G4 recognition by CX-5461 and MTR-106 is elucidated, and a structural framework for the rational development of next-generation G4-targeted therapeutics with improved selectivity and efficacy is provided.

Yubo Li, Kefu Liu, Xiaodong Hu et al. · Nucleic Acids Research · 1 citation