Open access
Aug 2026
Lactylation at H3K18 drives pathological angiogenesis via metabolic-epigenetic crosstalk in ischemic retinopathy
In vivo rescue experiments confirmed that ETS1 overexpression reversed the suppression of pathological neovascularization in OIR mice treated with AAV-Pfkfb3-RNAi, providing a promising therapeutic avenue for ischemic retinal diseases.
Xin Chen, Yuhan Jiang, Wei Qian et al.
· Theranostics · 0 citations