Author

Xiaojie Chu

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Open access Aug 2026

Surface and global proteomics identify ROR2 and other proteins as potentially actionable immunotherapeutic targets in osteosarcoma

SUMMARY Osteosarcoma (OS) is the most common human primary bone cancer, primarily affecting children and young adults. While the survival rate of patients diagnosed with localized OS is ~65%, this decreases to ~20% for patients with metastatic disease, and recurrent disease remains largely incurable. Therefore, identif...

Brian Mooney, Xiaojie Chu, G. Negri et al. · Cell Reports · 0 citations

#machine learning Open access Jun 2025

AntiBMPNN: Structure‐Guided Graph Neural Networks for Precision Antibody Engineering

AntiBMPNN consistently outperforms AbMPNN, AntiFold, and ProteinMPNN in designing complementarity determining regions (CDR) 1‐3, yielding stronger binding affinities and confirming its potential to improve therapeutic antibody design.

Ze-Yu Sun, Jiayi Yuan, Divya Jaiswal et al. · Advancement of science · 9 citations