Open access
Jul 2026
Modeling immune responses to autologous and allogeneic human stem cell-derived islet grafts in vivo 2332710
Stem cell-derived β cells offer a promising strategy for Type 1 diabetes (T1D) treatment, yet the mechanisms driving immune infiltration and graft rejection remain unclear. Using human immune system (HIS) mice, we sought to compare immune responses to autologous versus allogeneic iPSC-derived islet grafts and to...
Giorgia Zanetti, Camillo Bechi Genzano, Sakshi Bhatele et al.
· Journal of Immunology · 0 citations