Author

Xiaolin Wang

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Open access Sep 2026

Genome stability disrupted by the circRBM39(4,5,6)-RPA2 axis represses breast tumorigenesis.

Genome instability (GI) is a hallmark of cancer. GI is associated with accumulative DNA damage and tumor-specific defects in DNA repair. Multiple antitumor drugs have been developed to promote persistent GI and to drive DNA damage beyond a threshold that tumor cells can survive. However, regulatory roles of circular RN...

Xing Bian, Mao-Yi Xu, Na Li et al. · Proceedings of the National... · 0 citations

Open access Jul 2026

GBP6 maintains mitochondrial bioenergetics to promote immune evasion from NK cells in cervical cancer.

Metabolic reprogramming and immune evasion are central hallmarks of cancer progression; yet, how mitochondrial metabolism shapes immune escape remains unclear. Here, we identify GBP6 as a tumor-intrinsic mitochondrial factor associated with aggressive cervical cancer. GBP6 is enriched in high-risk tumors and correlates...

Lili Qian, Yue-Bo Li, Jiani Zheng et al. · Cell Reports · 0 citations