Xiaomei Yan

Overcoming Steric Hindrance for Precise Multiplexed Protein Profiling of Single Extracellular Vesicles.

Multiplexed protein profiling of single extracellular vesicles (EVs) is crucial for precise liquid biopsy but is severely limited by steric hindrance arising from bulky detection probes. This study systematically deconstructs the sources and consequences of this limitation using high-sensitivity nano-flow cytometry (nF...

Bispecific cell engagers: Evolving construction strategies, clinical progress, and future perspectives

Characterization of nanoparticles and fluorescent recombinant extracellular vesicles using three different generations of high-sensitivity flow cytometers

Aim: High-sensitivity flow cytometry (FC) allows multiparametric analysis of nanoparticles (NPs) and extracellular vesicles (EVs). With new instruments available, studies that evaluate their performance using the same materials in a controlled environment are required. Here, we performed a comparative study to investig...