Author

Xiaoning Qian

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Open access Aug 2026

Optimizing protein design through uncertainty-weighted steering of protein language models

PROSOUNDS (PROtein Sequence Optimization through UNcertainty-weighteD Steering), a PLM-based protein design framework that integrates uncertainty quantification into the activation steering logic enables robust protein optimization through precise mutational design even in the absence of ground-truth labels.

Alif Bin Abdul Qayyum, Ying-Tong Zhou, Xiaoning Qian et al. · Bioinformatics · 0 citations

Aug 2026

Integrating Data Cleaning and Robustification: A Study on Linear Regression

A general framework is proposed that integrates both optimistic and pessimistic optimization approaches in solving the regression problem to address outlier cleaning and robustification in a unified fashion and develops solution methods that can be applied to handle data sets of different scales.

Utku Tarık Bilgiç, Xiao-Ning Qian, Bo Zeng · INFORMS journal on computing · 0 citations