Tumor cells often evade immune pressure via metabolic reprogramming, yet the key metabolic regulators orchestrating this process remain incompletely defined. Here, using in vivo metabolic CRISPR screening under distinct immune pressures, we identified tumor cell-intrinsic solute carrier family 1 member 5 (SLC1A5) as a...
Wen-Long Jia, Guan-Xing Yu, Shen-Qi Han et al.· Science immunology· 0 citations
Across various cancer entities, a wide array of subtypes of B cells that infiltrate tumors can be identified. These subtypes confer these cells with high adaptability in their functions and significant involvement in tumor progression. Tumor-infiltrating B cells act as distinctive microenvironmental mediators that buil...
Hao Zhang, Kun Cheng, Jie Mo et al.· Signal Transduction and Targ...· 0 citations
This review systematically outlines recent advances in cell therapy strategies, focusing on their mechanisms of action, target antigens, and clinical translation.
Guisha Zi, Lei Zhang, Ling Zhou et al.· Signal Transduction and Targ...· 0 citations
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