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Xiaoping Chen

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Sep 2026

In vivo CRISPR screens identify the glutamine transporter SLC1A5 as a metabolic barrier to antitumor immunity.

Tumor cells often evade immune pressure via metabolic reprogramming, yet the key metabolic regulators orchestrating this process remain incompletely defined. Here, using in vivo metabolic CRISPR screening under distinct immune pressures, we identified tumor cell-intrinsic solute carrier family 1 member 5 (SLC1A5) as a...

Wen-Long Jia, Guan-Xing Yu, Shen-Qi Han et al. · 0 citations
Review Open access Sep 2026

B cells in cancer: functions, mechanisms and therapeutic advances

Across various cancer entities, a wide array of subtypes of B cells that infiltrate tumors can be identified. These subtypes confer these cells with high adaptability in their functions and significant involvement in tumor progression. Tumor-infiltrating B cells act as distinctive microenvironmental mediators that buil...

Hao Zhang, Kun Cheng, Jie Mo et al. · 0 citations

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