Author

Xiaoshan Zhao

2 papers indexed here

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Open access Aug 2026

Lactylation-dependent DDX18 nucleolar escape regulates CD44 mRNA stability to drive fibrotic progression in kidney injury

It is demonstrated that lactate drives sustained renal damage through posttranslational lactylation of the RNA helicase DDX18, and protein lactylation is established as a regulatory mechanism governing RNA helicase nucleolar localization and subsequent control of mRNA stability, revealing a potential therapeutic target...

Li-Jun Dong, Jing-Wen Xie, Meng-Yuan Tao et al. · Journal of Clinical Investig... · 0 citations

Open access Sep 2026

Limonin ameliorates hyperuricemia-induced cognitive impairment through modulation of microglial HIF-1α-driven neuroinflammation.

LIM ameliorates HUA-induced cognitive impairment by suppressing microglial activation and neuroinflammation, which is associated with the inhibition of the HIF-1α/iNOS signaling pathway, underscoring its therapeutic potential.

Jie Chen, De-Xian Li, Xiao-Hu Chen et al. · International Immunopharmaco... · 0 citations