Author

Xin Cai

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Sep 2026

Lactate suppresses STING activation to promote tumor immune evasion.

Lactate, known for its metabolic functions, has recently emerged as a signaling molecule. In a recent issue of Immunity, Guo and colleagues report that lactate is a competitive antagonist of STING and propose an epidermal growth factor receptor (EGFR)-mediated signaling cascade that enhances lactate dehydrogenase A (LD...

Yuan Tian, Xin Cai · Cell Metabolism · 0 citations

Open access Sep 2026

Mitochondrial ATP promotes T cell differentiation through chromatin accessibility.

Immune elimination of chronic infection or cancer requires cytotoxic CD8+ T cells that adopt and maintain an effector phenotype. Cytotoxic T cell function is a bioenergetically demanding process. Here, we report the ability of D-α-hydroxybutyrate (DAHB) to act as a signaling molecule that increases mitochondrial ATP pr...

Charles Ng, Tak-Shun Fung, Da-Yi Li et al. · Cell · 0 citations