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Xin Chen

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Open access Sep 2026

AI-enabled multi-omics pharmacogenomic modeling guides resistance-aware multitarget optimization of venetoclax therapy in acute myeloid leukemia

Acute myeloid leukemia (AML) remains difficult to treat because profound molecular heterogeneity enables rapid adaptive resistance to targeted therapy. We developed an AI-driven pharmacogenomic pipeline that integrates genomic, transcriptomic, epigenetic, and clinical features to predict patient-specific response to ve...

Chen Wang, Zhi-Jie You, Si-Qi Chen et al. · 0 citations
Sep 2026

Clinical and genetic analysis of a family with 16p11.2 microduplication syndrome and variable multisystem manifestations.

This family provides a detailed clinical and genetic description of 16p11.2 microduplication carriers with prominent gastrointestinal motility and neuromuscular manifestations, thereby enriching the clinical characterization of this recurrent CNV and supporting substantial intrafamilial phenotypic heterogeneity.

Hai-Lun Huang, An-Kang Zhu, Zi-Yan Xu et al. · 0 citations

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