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Author

Xin Cheng

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Open access Aug 2026

Protective-Antigen Scaffold Nanoparticle Vaccine Overcomes Carrier-Induced Suppression and Immunosenescence to Protect against Pseudomonas aeruginosa Pneumonia

Multidrug-resistant Pseudomonas aeruginosa (PA) causes severe infections, with severe burden especially in older adults. Vaccines remain effective and are urgently needed despite immunosenescence. Self-assembling nanoparticles can enhance vaccine immunogenicity, but their translational use is constrained by the usele...

Yu-Hang Li, Hui Zhao, Meilin Wu et al. · 0 citations
Open access Aug 2026

Discovery of antimicrobial peptides from incomplete biosynthetic gene clusters to combat multidrug-resistant bacteria

An evolution-inspired approach to reconstruct and predict AMPs from partial BGCs is presented and a promising therapeutic candidate is introduced, NP001, which effectively counteracts polymyxin-resistant pathogens.

Ya‐Li Tang, Xin Cheng, Jing Zhou et al. · 0 citations

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