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Author

Xin-Chi Luan

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Oct 2026

Mcu upregulation triggers mitochondrial oxidative stress and cardiomyocyte injury after myocardial infarction yet is suppressed by Fto and Ythdf2 in an m6A-dependent manner.

It is demonstrated that elevated Mcu is positively associated with MI risk; excess Mcu triggers mitochondrial calcium overload, ROS buildup, mitochondrial membrane potential loss and respiratory chain damage to facilitate cardiomyocyte damage, whereas Mcu knockdown alleviate these pathological alterations.

Ruo-Lan Chen, Xue-Zhe Wang, Lu-Ning Qin et al. · 0 citations

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