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Author

Xin Dai

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Open access 2026

IL-23 promotes PD-L1 expression and tumor immune evasion via METTL16 pathway.

It is elucidated that IL-23 upregulates METTL16, which in turn enhances PD-L1 expression and facilitates tumor immune escape, which establishes the IL-23/METTL16/PD-L1 axis as a novel regulatory pathway and potential therapeutic target in cancer immunotherapy.

Xue-Shan Pan, Yue Wang, Jing-Jing Luo et al. · 1 citation
Open access Sep 2026

Tumor-intrinsic NSUN2 orchestrates immunosuppression in lung adenocarcinoma via the m5C-HDAC8-CCL5 axis

Insufficient T-cell infiltration is a major barrier to the efficacy of immune checkpoint inhibitors (ICIs) in lung adenocarcinoma (LUAD). We aimed to investigate how the tumor-intrinsic m5C methyltransferase NSUN2 shapes the immune landscape of LUAD. Nsun2 conditional knockout mice and syngeneic mice models were employ...

Wang-Yang Meng, Tong Lu, Ming-Yuan Du et al. · 0 citations

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