Guaianolide-type sesquiterpenes from Rhaponticum repens (L.) Hidalgo with anti-ischemic stroke activity.
Ischemic stroke (IS) is a severe central nervous system disorder with high mortality and disability rates, and microglia-mediated neuroinflammation exacerbates ischemic brain injury. In this study, the traditional ethnic medicine Rhaponticum repens (L.) Hidalgo was found to significantly inhibit lipopolysaccharide (LPS...