Author

Xin Gao

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Aug 2026

Fine-Tuning l -Arginine Biosynthesis and Bidirectional Dynamic Control Overcome Metabolic Bottlenecks for High-Titer l -Ornithine Production in Escherichia coli

l-Ornithine is a versatile amino acid with broad applications in the pharmaceutical, nutraceutical, and food industries. However, its efficient microbial production is constrained by a critical trade-off: excessive blockage of the downstream l-arginine pathway severely impairs cell growth, while intracellular l-ornit...

Yingying Guo, Jia-Zhan Wang, Zhi Zhang et al. · ACS Synthetic Biology · 0 citations

Sep 2026

Key enzyme optimization and multi-node metabolic flux regulation drive l-arginine production in Escherichia coli.

Microbial production of l-arginine is often constrained by tight metabolic regulation and insufficient precursor supply. Here a plasmid-free, non-auxotrophic Escherichia coli strain for high-level production of l-arginine was rationally engineered, based on our previous constructed strain G0 with 12.4 g/L l-arginine pr...

Xin Gao, An-Yi Wu, Zi-Teng Yang et al. · Bioresource Technology · 0 citations