Host-dependent effects of mcr-1 and mcr-8 on fitness, virulence, and transmission in Escherichia coli and Klebsiella pneumoniae
Introduction As one of the most common groups of clinical pathogens, Enterobacterales pose a serious threat to global public health due to their multidrug-resistance. Polymyxin serves as a last-line treatment for infections caused by Carbapenem-resistant Enterobacterales (CRE). The emergence and spread of the mobilized...