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Xin-Lei Fu

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Open access Sep 2026

Ghrelin attenuates hypoxia-induced mitochondrial oxidative stress damage in HTR-8/SVneo trophoblasts.

BACKGROUND Preeclampsia (PE) is a life-threatening complication of pregnancy. Hypoxia-induced mitochondrial damage, oxidative stress and apoptosis in trophoblasts are critical in PE pathogenesis. Ghrelin exerts protective effects in multiple tissues, but its role and mechanism in hypoxic trophoblasts remain unclear....

Wan-Ru Feng, Xin-Lei Fu, Ning-Ning Hu et al. · 0 citations
Open access Aug 2026

Combined hydrogen and oxygen therapy attenuates vascular cognitive impairment in rats via gut microbiota-derived SCFA-GPR41/PI3K/Akt/Nrf2 signaling

It is found that HHOS significantly improved spatial memory and reduced anxiety-like behaviors in BCCAO rats, and outperformed monotherapies by coupling microbiota-SCFA restoration with GPR41/PI3K/Akt/Nrf2-mediated antioxidant defense, supporting a novel dual-gas strategy for VCI.

Xin-Lei Fu, Meng-Zhuo Ma, Yujing Zhang et al. · 0 citations

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