Dihydroartemisinin suppresses YAP1/SP1-associated SLC6A6 expression to remodel taurine homeostasis and increase intratumoral CD8+T cells in hepatocellular carcinoma.
Taurine availability is critical for CD8+T-cell survival and effector function. Dihydroartemisinin (DHA), a bioactive artemisinin derivative, exhibits antitumor activity in hepatocellular carcinoma (HCC); however, whether DHA enhances CD8+T-cell antitumor immunity by remodeling taurine homeostasis remains unknown. In t...