siRNA-Loaded Metal-Organic Layers for Targeted Gene Silencing and Radiotherapy Enhancement.
Radiotherapy (RT) remains a cornerstone in cancer treatment; however, its therapeutic efficacy is often limited by tumor fibrosis and radioresistance, primarily driven by transforming growth factor-β (TGF-β) upregulation. To address these challenges, we developed a tris(bipyridyl)ruthenium(II)-based metal-organic layer...