Sep 2026
Bruceine D suppressed osteoclast formation via STAT3/NF-κB/NFATc1 signaling and protected postmenopausal osteoporosis
It is demonstrated that BD significantly inhibited RANKL-induced osteoclast differentiation in a dose-dependent manner without cytotoxic effects at effective concentrations, and protects against estrogen deficiency-induced bone loss by inhibiting the STAT3/NF-κB/NFATc1 signaling axis.
Si-Si Lin, Qing-Lan Yuan, Xin-Yi Yao et al.
· Molecular Biology Reports · 0 citations