Open access
Sep 2026
YAP-mediated mechanotransduction promotes hepatocellular carcinoma progression by targeting ATP1A1/CXCL1 axis.
It is demonstrated that increased matrix stiffness activates YAP/TEAD4-dependent transcriptional program and promotes ATP1A1 expression, thereby converting mechanical cues into chemical signaling output and finally promoting malignant phenotypes in the tumor.
Meng-Nan Zhang, Xin-Peng Wen, Jingyi Liu et al.
· Acta Pharmacologica Sinica · 0 citations