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Xin-Qi Song

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Open access Aug 2026

Characterization of two key cytochrome P450 enzymes in Isodon amethystoides and de novo production of 3α,15β-dihydroxy-ent-kaurene in yeast

This work identified two enzymes, IamCYP71D761 and IamCYP706V18, in Isodon amethystoides, which specifically mediate the C3α- and C15β-hydroxylation of ent-kaurene with high stereoselectivity and regioselectivity, respectively, generating 3, a key precursor in the biosynthesis of GLA.

Yan-Ying Chen, Xin-Qi Song, Ya-Nan Wang et al. · 0 citations
Jul 2026

Gram-scale production of forskolin in yeast through biosynthetic network elucidation and pathway optimization.

This study reconstructed an efficient biosynthetic pathway of forskolin in yeast and subsequently optimized its production efficiency through multidimensional engineering strategies including central carbon flux optimization, rate-limiting enzyme engineering, P450 electron transfer chain reinforcement, and fermentation...

Meiling Jiang, Hao Tang, Ying Ma et al. · 0 citations

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