Menispermum dauricum rhizome alkaloids ameliorate colitis by inhibiting mitochondrial DNA synthesis via the JAK2-STAT4-AK4 pathway.
BACKGROUND Ulcerative colitis (UC), a chronic inflammatory bowel disease with increasing global incidence, has inadequate existing treatments, highlighting the urgent need for new therapeutic agents and strategies. The total alkaloids from Menispermi Rhizoma (TAMR) has been clinically used to treat inflammatory disease...