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Author

Xin-Song Chen

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Open access Sep 2026

Highly resolved tumor architecture via matched spatial and nucleus transcriptomics from a single tissue section

Spatial transcriptomics often relies on reference-based deconvolution to infer cell types in a tissue context; however, public single-cell datasets can miss patient-specific biology. Here we introduce SIMPlex, a method that generates matched spatial and single-nucleus gene-expression profiles from the same 5 µm FFPE se...

Marcos Tito Machado, Meng-Xiao He, L. A. Galicia et al. · 0 citations
Open access Aug 2026

Patient characteristics, treatment patterns, and survival across estrogen receptor expression subgroups in HER2-negative breast cancer: a population-based cohort study

Summary Background Estrogen receptor (ER) low (1–9%) breast cancer (BC) often behaves like triple-negative BC, while ERhigh (≥60%) disease has a more favorable prognosis. However, tumors with ER expressing 10–59% represent a poorly defined patient population. In this nationwide cohort study, we aimed to describe real-w...

Qiao Yang, C. Boyaci, I. Zerdes et al. · 0 citations

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