Open access
Aug 2026
A multi-functional oral small molecule targeting energy and lipid metabolism to treat obesity and related metabolic disorders
Obesity and related metabolic disorders have surged globally, and are mechanistically interconnected through dysregulated energy and lipid metabolism pathways. Current incretin-based obesity treatments act to decrease food intake, but are associated with gastrointestinal side effects and muscle wasting. Here, we identi...
Justin Y. Lee, Chi Zhu, Melissa A. Boldridge et al.
· Science Advances · 1 citation