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Open access Aug 2026

CUDC-907 attenuates pulmonary fibrosis by reversing HDAC1-mediated SMAD4 deacetylation at lysine 45

Pulmonary fibrosis is characterized by the persistent activation of fibroblasts into myofibroblasts, a process largely driven by TGF-β/SMAD signaling. Acetylation has emerged as a fundamental regulatory mechanism in cellular homeostasis and tissue fibrosis, yet whether and how the acetylation of core SMAD transcription...

Yu Li, Yuan Cui, Hao-Yu Qiu et al. · 0 citations
Aug 2026

TWIST2-dependent transcriptional activation of TPI1 mediates TGF-β1-driven fibroblast activation in pulmonary fibrosis.

The TGF-β1/TWIST2/TPI1 signaling axis is defined as an important regulator of pathogenic fibroblast behavior and pro-fibrotic responses through transcriptional control of TPI1, highlighting its potential as a therapeutic target for IPF.

Jiawei Chen, Yu Li, Kai Fu et al. · 0 citations

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