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Author

Xin-Xiang Lei

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Aug 2026

Discovery of Cbl-b Targeting Cyclic Peptide Ligands by Phage Display.

Cbl-b is a RING-type E3 ubiquitin ligase and intracellular immune checkpoint that negatively regulates immune-cell activation. However, ligand discovery for Cbl-b remains limited, largely because the RING-type E3 ubiquitin ligase is regulated by shallow and extended protein-protein interaction interfaces that are diffi...

Xiao-Qin Yang, Ming Wei, Wei-Kang Zhai et al. · 0 citations
Sep 2026

Tyrosinase-Catalyzed Tyr–Aniline Coupling Enables Peptide Editing, Macrocyclization, and Phage-Display-Based Selection

Tyrosine-selective peptide modification provides a valuable route to late-stage diversification, yet current methods remain largely limited to site-specific labeling and rarely extend to macrocyclization or ligand discovery within a unified platform. Here, we report a tyrosinase-catalyzed tyrosine–aniline coupling pl...

Ming Wei, Xiang Liu, Xiao-Qin Yang et al. · 0 citations
Aug 2026

A Penta-Thiooxazole RiPP Confers Periplasmic Defense to Oxidative Stress in Pseudomonas aeruginosa

The discovery and characterization of aen gene cluster is reported, a previously uncharacterized MNIO-associated gene cluster in the opportunistic pathogen Pseudomonas aeruginosa PAO1, and a potential role for aeruginin in chlorite responsive periplasmic stress adaptation is suggested.

Zhuang-Zhuang Chu, Han-Zhong Feng, Hang Xu et al. · 0 citations

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