Author

Xin-Yi Tan

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Sep 2026

Mesenchymal Tumors Feature a Spatially Defined Glial-Tip Cell Niche Around the Tumor Boundary in Microsatellite-Stable Colorectal Cancer.

This study characterizes the spatial heterogeneity of tumor states and TME programs in CRC and provides a translational framework for improved CRC stratification and immunotherapy guidance.

Dong Zhang, Hui-Fang Chen, Liang Gu et al. · Cancer Research · 0 citations

Open access Aug 2026

H3.3 chaperone Hira primes the effector program and function of regulatory T cells

It is shown that the histone variant H3.3 is enriched in tissue Tregs compared to splenic Tregs and its chaperone Hira is a critical regulator of Treg effector program, revealing a previously unreported epigenetic mechanism critical for Treg effector differentiation and function.

Xiang-Xiang Cao, Meng-Jie Lv, Zhi-Han Lv et al. · Science Advances · 0 citations