The human brain undergoes profound changes from early development through late adulthood, shaping cognition, behaviour and vulnerability to disease1,2. Understanding how these changes are organized within specific brain regions and cell types is essential for interpreting normal ageing and its relationship to psychiatr...
Hui Yang, Tereza Clarence, Madeline R. Scott et al.· Nature· 3 citations
Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited1,2. Here, to gain deeper insights into the aetiology of different brain diseases, we used specimens f...
Donghoon Lee, Mikaela Koutrouli, Nicolas Y. Masse et al.· Nature· 5 citations
Neurogenesis, a critical process implicated in diverse brain disorders, is greatly diminished in the adult human brain, complicating direct investigations into its mechanistic role in disease. In the olfactory epithelium (OE), olfactory sensory neurons (OSNs) maintain homeostasis via continual neurogenesis throughout l...
Liting Song, J. Fullard, Claire Coleman et al.· Nature Communications· 0 citations
It is shown that a disease-associated microglial subtype, characterized by elevated GPNMB expression and enriched for polygenic AD risk, expands with AD pathology and shows increased phagocytic activity, and MITF is identified as an upstream regulator required to maintain this microglial state.
Donghoon Lee, James M. Vicari, Christian Porras et al.· Nature Genetics· 1 citation
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