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Author

Xin-Yi Yang

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2 papers indexed here

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Open access Sep 2026

Disrupted Estrogen Homeostasis Drives Female-Specific Depressive-Like and Anxiety-Like Behaviors via Convergent ERα Downregulation in the Ventral Hippocampus

Although depression exhibits prominent sex differences, mechanisms linking estrogen fluctuations to this vulnerability remain unclear. Here, we reveal that disrupted estrogen homeostasis induces depressive- and anxiety-like behaviors via convergent downregulation of estrogen receptor alpha (ERα) and subsequent neuroinf...

Zheng-Yang Wang, Yi-Kun Ren, Fei-Ran Cheng et al. · 0 citations
Sep 2026

D-Cycloserine ameliorates innate fear deficits in young adult male APP/PS1 mice: Involvement of GluN2B-containing NMDA receptor.

Neuropsychiatric symptoms can emerge early in Alzheimer's disease (AD), but whether innate fear is altered prior to amyloid plaque deposition remains unclear. This study aimed to examine innate fear responses in young adult male APP/PS1 mice and to evaluate whether D-cycloserine (DCS) rescues such deficits via GluN2B-c...

Bin Zhang, Zhe-Ye Wang, Xin-Jie Zhao et al. · 0 citations

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