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Author

Xin-Yi Zhang

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Oct 2026

Targeting the Immune-Neurovascular Interface to Ameliorate Pericyte Dysfunction with a Multifunctional Peptide–Drug Conjugate Nanoprodrug for Multiple Sclerosis Therapy

Pericyte dysfunction triggers blood–brain barrier (BBB) disruption and subsequent aberrant immune infiltration in multiple sclerosis (MS), yet targeted interventions remain lacking. Here, we engineered a dual-functional fusion peptide (VLC) for pericyte targeting and therapeutic intervention and subsequently conjugat...

Yong-Kang Mu, Kai-Chao Wen, Ling-Ling Zhou et al. · 0 citations
Sep 2026

Geraniin alleviates pathological visceral adipose tissue expansion through modulation of β-adrenergic receptor-associated cAMP-LKB1-AMPK signaling in high-fat diet-fed mice.

ETHNOPHARMACOLOGICAL RELEVANCE Geranium (Geranium wilfordii Maxim.) has traditionally been used as a folk medicine in East Asia and Europe. Geraniin, the major bioactive constituent of geranium, has been reported to ameliorate dyslipidemia and insulin resistance, but its effects against adipose metabolic dysfunction re...

Yi Feng, Xiao-Yu Liu, Xin-Yi Zhang et al. · 0 citations

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