Xin-Yi Zhang

Glucocorticoid receptor signaling protects human mature adipocytes from metabolic stress and is impaired in obesity.

BACKGROUND Obesity-associated adipose tissue dysfunction is a major contributor to metabolic disease. Although obesity is associated with increased glucocorticoid exposure, the role of glucocorticoid receptor (GR) signaling in mature adipocytes during obesity remains unclear. METHODS AND RESULTS To investigate the di...