Review
Open access
Sep 2026
The Lactate–Lactylation Axis as a Metabolic–Epigenetic Framework for Therapeutic Adaptation in Esophageal Squamous Cell Carcinoma
Simple Summary Esophageal squamous cell carcinoma is an aggressive cancer in which treatment failure can reflect adaptation by tumor cells and the surrounding immune environment to chemotherapy and immunotherapy. Lactate, traditionally viewed as a glycolytic byproduct, can also influence gene expression and protein fun...
Jing-Jie Yu, Yi-Yuan Cui, Si-Cong Li et al.
· Cancers · 0 citations