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Open access Sep 2026

Andrographolide Promotes Post-Ischemic Endothelial Angiogenic Activity via IL-10-Mediated M2-Like Microglia–Endothelial Crosstalk Involving Endothelial VEGFR2 Upregulation

Ischemic stroke remains a leading cause of disability worldwide, and angiogenesis is critical for functional recovery. Although andrographolide (ANP) has anti-inflammatory and neuroprotective properties, its role in post-stroke angiogenesis remains unclear. Here, we investigated whether ANP promotes post-ischemic angio...

Hong-Fei Li, Hai-Rong Xiang, Xin-Yu Li et al. · 0 citations
Review Open access Jul 2026

Microglia-Mediated Vascular Network Remodeling After Ischemic Stroke: An Immunovascular Repair Framework

Ischemic stroke remains a leading cause of death and long-term disability worldwide. Although acute reperfusion therapies have improved outcomes in selected patients, effective strategies that directly promote neurovascular repair during the subacute and chronic phases remain limited. Vascular network remodeling in the...

Xin-Yu Li, Xiang Li, Yushi Li et al. · 0 citations

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