Author

Xinyu Wang

3 papers indexed here

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Review Aug 2026

Hepatotoxicity in the Era of Precision Medicine: Toxicological Mechanisms and Management of Immune and Cell Therapy-Induced Liver Injury.

Immune checkpoint inhibitors and adoptive cell therapies have revolutionized cancer treatment, yet their success is accompanied by immune-related hepatotoxicity that can range from asymptomatic enzyme elevation to life-threatening liver failure. Unlike conventional drug-induced liver injury, immune-mediated hepatotoxic...

Yu-Jian Fan, Xiao-Kai Guo, Jiaying Lyu et al. · Medicinal research reviews (... · 0 citations

Review Open access Sep 2026

Planetary health and pharmacology: Addressing the ecological impact and circular threat of pharmaceuticals.

A mechanistic analysis of pharmaceutical ecotoxicity demonstrates that effective intervention requires targeting root causes across the pharmaceutical lifecycle rather than relying on end-of-pipe remediation, and that integrating environmental sustainability into pharmaceutical safety assessment is essential for protec...

Yu-Jian Fan, Xiao-Kai Guo, Jiaying Lyu et al. · Ecotoxicology and Environmen... · 0 citations

Review Jul 2026

The long shadow: a toxicological review of chronic exposure, biopersistence, and latent health risks of engineered nanomaterials.

An integrated risk assessment framework is proposed that combines adverse outcome pathway analysis, physiologically-based pharmacokinetic modeling, new approach methodologies, and safe-by-design principles to enable predictive hazard identification and supports evidence-based regulation of existing ENMs while enabling...

Yu-Jian Fan, Jiaying Lyu, Xiao-Kai Guo et al. · Journal of materials chemist... · 0 citations