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Author

Xinyu Xiang

2 papers indexed here

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Open access Sep 2026

MHC restriction is structurally encoded by the T cell receptor germline

MHC restriction — the requirement for αβ T cell receptors (TCRs) to recognize Major Histocompatibility Complex (MHC) molecules when presenting peptide antigens — is a pillar of adaptive immunity. Here, we provide direct structural evidence for TCR germline-encoded recognition of MHC molecules irrespective of antigenic...

Nan Wang, Marta T. Borowska, K. Jude et al. · 0 citations
Open access Aug 2026

Functional Pairing of TCR-peptide-MHC Interactomes by Single-cell Clonal Expansion

The LINC-seq platform, LINC-seq, recovered known cognate pairs from pooled libraries at up to 95% accuracy and performed simultaneous, library-on-library deep mutational scanning of both partners, and generalizes to any receptor-ligand pair whose trans-engagement drives a reporter.

L. Liu, Seung Won Shin, Kevin M. Joslin et al. · 0 citations

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