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Xin-Yuan Hu

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Sep 2026

Discovery of Novel 2-(2-Benzimidazole)-Substituted Tetrahydrofur-ans as Potent and Selective NaV1.8 Inhibitors for the Treatment of Pain

Selective inhibition of voltage-gated sodium channel 1.8 (NaV1.8) is a validated non-opioid analgesic strategy. Guided by the well-documented metabolic features of marketed VX-548 in humans and rats, we conducted rational structural optimization to circumvent its major reported metabolic pathways while preserving tar...

Yong-Qi He, Xin-Yuan Hu, Xin-Yu Leng et al. · 0 citations

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