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Xin-Yuan Shen

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Open access Sep 2026

Adoptive MAIT cell therapy for liver cancer enhanced by multimodal modulation of immune receptors and checkpoints.

BACKGROUND Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that recognize riboflavin-derived metabolites presented by the monomorphic major histocompatibility complex (MHC)-class I-related molecule MR1. MAIT cells are highly enriched in the human liver and are increasingly implicated in liver...

Yan-Ruide Li, Xin-Yuan Shen, Yi-Chen Zhu et al. · i Medicina · 0 citations

Sep 2026

Abstract B100: Targeting orthotopic and metastatic pancreatic cancer with allogeneic stem cell–engineered mesothelin-redirected CAR-engineered invariant natural killer T cells

Pancreatic cancer (PC) remains one of the leading causes of cancer-related mortality worldwide, with most patients diagnosed at advanced stages and more than half presenting with metastatic disease at diagnosis. Although chimeric antigen receptor (CAR)-T cell therapy has shown promise for the treatment of PC, its cli...

Yan-Ruide Li, Xin-Yuan Shen, En-Bo Zhu et al. · Cancer Research · 0 citations

Open access Aug 2026

Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors

HSPC-derived AlloESO-T cells are established as an off-the-shelf, mono-specific cytotoxic T cell therapy with scalable manufacturing, enhanced efficacy, and improved safety, which support broad applicability of AlloESO-T cells across solid tumors.

Yi-Chen Zhu, Jia-Ji Yu, Y. J. Kim et al. · Cell Reports Medicine · 0 citations