Histone deacetylases (HDACs) are key regulators of chromatin architecture and gene expression, and their dysregulation is closely linked to tumorigenesis, making them attractive targets for cancer therapy. Histone deacetylase inhibitors (HDACis) exert broad antitumor effects by modulating both epigenetic and non-epigen...
Kun Liu, Xiang Zhao, Jia-Hui Liu et al.· Frontiers in Cell and Develo...· 0 citations
Lactate accumulation occurs in diverse physiological and pathological states, including hypoxia, ischemia, development, wound healing, immune activation, and cancer, where it functions as a key regulator of cellular energy metabolism, signal transduction, microenvironmental homeostasis, and immune responses. Protein la...
Xiang Zhao, Jia-Hui Liu, Kun Liu et al.· Frontiers in Cell and Develo...· 0 citations
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